Osteopontin
Modulator score = 955
(score < 50 : weak, score ≥ 50 : solid )

Experimental evidence∑experimental score = 950

Modulator functions

number of references  19

Crystal crystallization

PMID/DOI Title name Year
PMID:22503630 On the catalysis of calcium oxalate dihydrate formation by osteopontin peptides. 2012
PMID:18611047 Phosphorylation of osteopontin is required for inhibition of calcium oxalate crystallization. 2008
PMID:17898038 Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. 2007
PMID:9453018 Contribution of human uropontin to inhibition of calcium oxalate crystallization. 1998

Crystal growth

PMID/DOI Title name Year
PMID:23611580 Reversible inhibition of calcium oxalate monohydrate growth by an osteopontin phosphopeptide. 2013
PMID:21883862 The effect of intracrystalline and surface-bound osteopontin on the attachment of calcium oxalate dihydrate crystals to Madin-Darby canine kidney (MDCK) cells in ultrafiltered human urine. 2011
PMID:19189038 Kinetics of calcium oxalate crystal growth in the presence of osteopontin isoforms: an analysis by scanning confocal interference microcopy. 2009
PMID:19581305 Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning. 2009
PMID:18728346 Phosphorylation of osteopontin peptides mediates adsorption to and incorporation into calcium oxalate crystals. 2008
PMID:17994739 Control of calcium oxalate crystal growth by face-specific adsorption of an osteopontin phosphopeptide. 2007
PMID:14766970 Molecular modulation of calcium oxalate crystallization by osteopontin and citrate. 2004
PMID:12706004 The role of osteopontin on calcium oxalate crystal formation. 2003
PMID:9453018 Contribution of human uropontin to inhibition of calcium oxalate crystallization. 1998
PMID:8839390 Identification of a macromolecular crystal growth inhibitor in human urine as osteopontin. 1995
PMID:1414495 The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin. 1992

Crystal aggregation

PMID/DOI Title name Year
PMID:15864572 Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. 2005
PMID:12706004 The role of osteopontin on calcium oxalate crystal formation. 2003
PMID:9453018 Contribution of human uropontin to inhibition of calcium oxalate crystallization. 1998

Crystal-cell adhesion

PMID/DOI Title name Year
PMID:16164655 Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. 2005
PMID:9453018 Contribution of human uropontin to inhibition of calcium oxalate crystallization. 1998
PMID:9751404 Osteopontin antisense oligonucleotide inhibits adhesion of calcium oxalate crystals in Madin-Darby canine kidney cell. 1998
PMID:9067899 Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals. 1997
PMID:7733317 Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions 1995
Predicted evidence∑predicted score = 5

Oxalate-binding