Prothrombin (PT)

General Information

Protein

Common name	Prothrombin (PT)
Alternative name	Coagulation factor II
UniProt ID	P00734
Isoform	P00734
Proteomic database

Protein Atlas	P00734
PeptideAtlas	P00734

Gene

Gene name	coagulation factor II, thrombin
Gene symbol	F2
Genome annotation database

Ensembl

ENSG00000180210

Modulatory effects

Crystallization

No evidence

Crystal growth

Inhibitor

number of references 3

Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. (2004)

Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. (1999)

Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. (1999)

Crystal aggregation

Inhibitor

number of references 3

Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity. (2002)

Inhibition of calcium oxalate crystal growth and aggregation by prothrombin and its fragments in vitro: relationship between protein structure and inhibitory activity. (1999)

Prothrombin gene expression in rat kidneys provides an opportunity to examine its role in urinary stone pathogenesis. (1999)

Crystal adhesion

Inhibitor

number of references 1

Urinary macromolecular inhibition of crystal adhesion to renal epithelial cells is impaired in male stone formers. (2005)